PECULIARITIES OF PINOPODS FORMATION IN ENDOMETRIUM DEPENDING ON LUTEAL PHASE SUPPORT IN CYCLES OF IN VITRO FERTILIZATION

Abstract

The formation of pinopods occurring in the middle of the luteal phase is a major indicator of the quality of the endometrium. The study is aimed at studying the peculiarities of pinopod formation in the endometrium, depending on the method of maintaining the luteal phase in the treatment of infertility by means of in vitro fertilization. To this end, 50 women being the oocyte donors were examined. They were subdivided into five subgroups depending on the luteal phase support scheme. On the 5th day after receiving oocytes, women underwent endometrial tube biopsy to scan electron microscopy and determine foam events in the endometrium. It has been proven that in patients receiving highly purified progesterone for subcutaneous administration of 25 mg (1 ml) once a day and 90 mg of intra−vaginal progesterone as a gel, normal development of pinopods was observed in 60.0 % of cases. This scheme proved to be the most effective. Therefore, for the success of extracorporeal fertilization, the process of forming pinopods, which depends on the scheme of maintaining the luteal phase of the cycle, is important. It is noted that the common negative features in the formation of pinopods in women during the period of "implantation windows" is a decrease in the number of pinopod events, an increase in the number of foam events, the presence of areas of pinopod absence, mosaicism of their sizes, forms and stages of development. Key words: pinopods, luteal phase support, endometrium, in vitro fertilization.