Research Methodology and Mechanisms of Action of Current Orthopaedic Implant Coatings

Author:

Syeddan Syed Abdullah

Abstract

Orthopedic implants are crucial interventions that are gaining greater importance in modern medicine to restore function to commonly affected joints. Each implantation carries the risk of implant-associated infection and loosening of the implant due to improper integration with soft tissue. Coating strategies have been developed to aid the growth of bone into the implant (osteointegration) and prevent biofilm formation to avoid infection. In this review, primary articles highlighting recent developments and advancements in orthopedic implant coating will be presented. Additionally, the methodology of the articles will be critiqued based on this research criteria: establishment of function on a theoretical basis, validation of coating function, and potential next steps/improvements based on results. A theoretical basis based on understanding the mechanisms at play of these various coatings allows for systems to be developed to tackle the tasks of osteointegration, subversion of infection, and avoidance of cytotoxicity. The current state of research methodology in coating design focuses too heavily on either osteointegration or the prevention of infection, thus, future development in medical implant coating needs to investigate the creation of a coating that accomplishes both tasks. Additionally, next steps and improvements to systems need to be better highlighted to move forward when problems arise within a system. Research currently showcasing new coatings is performed primarily <i>in vitro</i> and <i>in vivo</i>. More clinical trials need to be performed to highlight long-term sustainability, the structural integrity, and the safety of the implant.

Publisher

Begell House

Subject

General Dentistry,Biomedical Engineering

Reference75 articles.

1. Rates of total joint replacement in the United States: Future projections to 2020-2040 using the national inpatient sample;Singh J.A.;J Rheumatol,2019

2. Gristina AG, Naylor PT, Myrvik Q. The race for the surface: Microbes, tissue cells, and biomaterials. In: Switalski L, Hook M, Beachey E, editors. Molecular mechanisms of microbial adhesion. New York, NY: Springer; 1989. p. 177-211.

3. Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants;Raphel J.;Biomaterials,2016

4. Biofilms and their properties;Valen H.;Eur J Oral Sci,126

5. Odekerken JC, Welting TJ, Arts JJ, Walenkamp GHIM, Emans PJ. Modern orthopaedic implant coatings - their pro's, con's and evaluation methods. In: Aliofkhazraei M, editor. Modern surface engineering treatments. London: IntechOpen; 2013.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3