Heavy metal toxicity poses a serious danger to the environment and its inhabitants on a global scale. The harmful heavy metals that are not necessary but are still dangerous, such as lead, arsenic, cadmium, and mercury are frequently linked to pollution and the resulting health problems. Despite several gross ill effects, toxic heavy metals have been found to show beneficial biological activity when applied at very low or trace levels. This article aims to collate such investigations conducted during the last two decades with trace levels of cadmium, mercury and arsenic toxicity against animal systems. There are a total of 13 pre-clinical works demonstrating the protective or beneficial effect of mercury, cadmium and arsenic at trace levels. Such literature reports with lead could not be found. From the outcome of the current literature investigation it is evident that, trace levels of toxic heavy metals namely arsenic, cadmium and mercury possess remarkable protective and beneficial effects chiefly on growth, developmental and reproductive parameters against animal systems pre-clinically, in contrast to their known toxic effects-operated by multiple mechanisms which provided some empirical support for further understanding of the outranged biological functions of the heavy metals. Further mechanistic works on this sphere may pave the way for a better understanding of the protective role of toxic heavy metals for the accomplishment of animals including humans.