Polyacetylene Derivatives from the Polypore Fungus (Fistulina hepatica, Agaricomycetes) and Their Antimicrobial Activity

Abstract

Chemical investigation of the polypore fungus <i>Fistulina hepatica </i>resulted in the isolation of five compounds, including four new polyacetylenic fatty acid derivatives - isocinnatriacetin B (1), isocinnatriacetin A (2), cinna-triacetin C (3) and ethylcinnatriacetin A (4) together with one known polyacetylene fatty acid derivative - cinnatriacetin A (5). The structures were elucidated using spectroscopic methods (UV, NMR, HR-ESIMS) along with comparison to literature data. Antibacterial activity screening of compounds <b>1-5</b> against ESKAPE bacterial strains <i>in vitro</i> with zones of inhibition (ZOI) was performed and MIC values were established for the most active compounds (<b>3 </b>and <b>4</b>). Together with that morphological and growth parameters under solid-phase cultivation were also researched.