Cold Atmospheric Plasma Benefits after a Biopsy of the Gingiva and Palate: A Case Series

Abstract

When an oral biopsy is performed, wound healing depends on the formation of blood clots that resist mechanical forces. Mainly, when the biopsy is performed in the gingiva and palate area, the wounds are not easy to suture due to the type of tissue or area in which it is located. In this work, ten patients over 18 years of age with lesions located on the palate and gingiva required an excisional biopsy. A needle-type reactor powered by a radio frequency (RF) source was used to generate cold atmospheric plasma (CAP) for the healing wound. After placing the tip of the reactor on the wound after performing the biopsy, the CAP was applied to the wound through scanning. The time it took for the wound to heal after the biopsy was recorded in days. The wound achieved clinical repair time between one and seven days, where none of the patients undergoing treatment with CAP showed adverse effects. Significant tissue regeneration time was reduced, with an average of four days, without infection and absence of postsurgical pain, resulting in the almost immediate recovery of oral functions.