Author:
Malysheva I.,Topchieva L.,Tikhonovich E.,Barysheva O.,Volkova T.
Abstract
Aim. To analyze the associations of the -238G>A polymorphism of TNF gene with susceptibility to pulmonary sarcoidosis in ethnic Russian patients of Karelia republic. Subjects and methods. The distribution of alleles and genotypes of the -238G>A polymorphism of TNF gene was studied in 84 patients with pulmonary sarcoidosis and 96 healthy controls. The polymorphic alleles were identified by polymerase chain reaction-restriction fragment length analysis. Results. Comparative analysis revealed no significant differences in the frequency of the alleles of the -238G>A polymorphism of TNF gene in investigated groups. Conclusion. The -238G>A polymorphism of TNF gene is not associated with the risk of pulmonary sarcoidosis in ethnic Russian patients of Karelia republic
Publisher
All-Russian National Academy of Mycology
Subject
Industrial and Manufacturing Engineering,Metals and Alloys,Strategy and Management,Mechanical Engineering
Cited by
3 articles.
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