The effect of oral administration of robenacoxib on hematological and biochemical parameters in different goat breeds

Abstract

Robenacoxib is a coxib-class, highly selective cyclooxygenase-2 inhibitor that is used for the control of pain and inflammation. This study aimed to determine the effect on hematological and biochemical parameters 24 hours after oral administration of robenacoxib to healthy Alpine and Saanen goats. The study was conducted on healthy females, 1-2 years old Alpine (n=5) and Saanen (n=5) goats. A single dose of robenacoxib was administered orally to goats at a dose of 4 mg/kg body weight. Blood samples were taken before (0 hour) and 24 hours after the administration of robenacoxib for the evaluation of hematological and biochemical changes. The results of this study showed that statistical differences in hematological and biochemical parameters were within the normal limits in Alpine and Saanen goats except lactate dehydrogenase in Saanen goats. Furthermore, no differences were observed in hematological parameters between goat breeds; it can be claimed that the Alpine breed is more susceptible to negative pharmacological side effects than the Saanen breed according to changes in biochemical parameters. As a result, it was concluded that robenacoxib did not have a negative effect on kidney and liver functions and blood components in Alpine and Saanen goats in administered dose and treatment period in this study. Further studies need to investigate the effects of robenacoxib in high doses, long-term use, and in disease conditions, especially on the kidney.