Evaluation of some biomarkers of osteoporosis in women with breast cancer in Al-Najaf Governorate

Abstract

Introduction: Osteoporosis is a systemic disease that affects the mineral density of bones and their structure, which leads to an increase in the softness of the bones. One in three women after the age of fifty worldwide is affected. Both breast cancer and osteoporosis are common diseases in women.  Breast cancer is the most common type of cancer in women, with one in eight women developing breast cancer in their lifetime.Aim of the study       Evaluation of some biomarkers of osteoporosis in women with breast cancer represented by cathepsin K, parathyroid hormone, calcium and vitamin D. methods: The current study was conducted at the National Cancer Center in Al-Najaf province for the period from 8/15/2022 to 1/20/2023. The study included 60 women with breast cancer and 30 healthy women free of diseases, and it was considered a control group. The ages of patients and healthy people ranged between (30-68) years old, vitamin D, calcium, parathyroid hormone, and cathepsin K were evaluated. Results: For the indicators of vitamin D and parathyroid hormone (PTH), the results of the statistical analysis did not record any significant difference (p>0.05) between the two groups under study. The results of the statistical analysis showed a significant increase (p<0.0001) in the levels of calcium (Ca) and cathepsin K in infected women compared with healthy women.  Likelihood (p < 0.005) and calcium with a probability level (p < 0.0001). Conclusion    Depending on the results reached through the current study, we conclude that there is a high rate of osteoporosis in women with breast cancer. prevalent. Also, an increase in the level of calcium in women with breast cancer, with no difference in parathyroid hormone, which is the most important biomarker for breast cancer diagnosis. An increase in the level of cathepsin K and its negative effect on the level of calcium in women with breast cancer.