The Role Of MicoRNA 146-A (Rs2910164) In Otitis Media Patients In AL-Najaf Provenance/Iraq-Reference-Cited by-同舟云学术

The Role Of MicoRNA 146-A (Rs2910164) In Otitis Media Patients In AL-Najaf Provenance/Iraq

Published:2023-12-31 Issue:3 Volume:15 Page:8-13
ISSN:2311-6544
Container-title:Al-Kufa University Journal for Biology
language:
Short-container-title:Kufa Jour. Bio.

Author:

Mohammed Hadi Al-fatlawi Manar,Alammar Mahdi,Lafta Al Mansoori Yaser

Abstract

The current study aims to shows the relationship between gene polymorphisms (SNP( of miRNA 146-a of patients infected with otitis media. This finding included 50 samples collected from healthy subject and 100 samples from a patienst suffering from otitis media who attended Al-Sadr Medical City (ENT Department) in Al-Najaf Governorate during the period from February 2022 to June 2022. The samples had an average age ranging from 5 to 70 years. Genotyping of miRNA 146-a revealed the presence of three genotypes: GG, CG, and CC, representing (16%, 47%, and 37%) respectively in patients with otitis media, while it was (27%, 18%, and 55%) respectively in healthy subjects. CG was common in patients while GG was more common in healthy subjects. MiRNA as potential biomarker of patients infected with otitis media.

Publisher

University of Kufa

Reference35 articles.

1. Suzuki, H. G., Dewez, J. E., Nijman, R. G., & Yeung, S. (2020). Clinical practice guidelines for acute otitis media in children: a systematic review and appraisal of European national guidelines. BMJ open, 10(5), e035343.

2. Bergenfelz, C., & Hakansson, A. P. (2017). Streptococcus pneumoniae otitis media pathogenesis and how it informs our understanding of vaccine strategies. Current otorhinolaryngology reports, 5, 115-124.‏

3. Venekamp, R. P., Schilder, A. G., van den Heuvel, M., & Hay, A. D. (2020). Acute middle ear infection (acute otitis media) in children. bmj, 371.

4. Deniz, Y., van Uum, R. T., de Hoog, M. L., Schilder, A. G., Damoiseaux, R. A., & Venekamp, R. P. (2018). Impact of acute otitis media clinical practice guidelines on antibiotic and analgesic prescriptions: a systematic review. Archives of Disease in Childhood, 103(6), 597-602.‏

5. Schilder, A. G., Chonmaitree, T., Cripps, A. W., Rosenfeld, R. M., Casselbrant, M. L., Haggard, M. P., & Venekamp, R. P. (2016). Otitis media. Nature reviews Disease primers, 2(1), 1-18.