Abstract
New glycolipids on glucose have been synthesized according to well-known sequencing reactions. The series of reactions started with peracetylation of glucose to produce mainly β-anomer, which is reacted directly with long chain alcohol in presence of Lewis acid as catalyst. The deacetylation of sugar head group was achieved under basic conditions. The resulting glycolipids have been modified in more three reaction steps to get the final products. The modified glycolipids have been studied under POM and DSC to confirm the phase behavior of these type of amphiphilic molecules, which is indicate that most of them form lamellar phase. These materials were also studied against two types of cancer cells to confirm their ability to interfere the bi-layer membrane of the living cell.