Evaluation of Cryoglobulin Rheumatoid Factors concentration and Total IgG and IgA Levels Among Rheumatoid Arthritis Patients

Abstract

Background:  rheumatoid arthritis is a common autoimmune disease that may affect many tissues and organs, but principally attacks flexible (synovial) joints., The pathology of the disease process often leads other systemic complications, Many individuals with rheumatoid arthritis produce a group of auto –Ab, called rheumatoid factors and anti-citrullinated peptide antibodies (ACPA).Materials and methods: from 58 rheumatoid arthritis patients , blood samples were collected and processed for manifestation on the rheumatoid factors , cryoglobulin,total IgG and IgA levelsanalyzed by ELISA, and erythrocytes sedimentation rate (ESR).Results: the present study demonstrates that the difference between  concentrations of  R.F in whole serum and cryoprecibitable R.F of the same rheumatoid arthritis patients was non significant.additionally slight elevation of the IgG level compared with healthy persons, while the  increase level of IgA in serum of Reumatoide arthritis patients compared with those of  health persons was statistically significant, as well as the increase  of  ESR level among patients group compared with the control sample was significant.Conclusion:cryoglobulin level increase associated with severity grade of rheumatoid arthritis and the level of IgA  refers to severity of  the joints damage and complication of diseases .