Assessment of Thrombospondin-1 Level in Type II Diabetic Patients

Abstract

    The study is intended to asses serum levels of Thrombospondin-1, fasting blood glucose  in type 2 diabetic patients, also  correlation between   Thrombospondin-1 in both males and females.     The study was conducted on randomly selected 65 type 2 diabetic patients (34 males and 31 females) attending the diabetes mellitus center in Al-Sadder Teaching City in Al- Najaf province , Iraqi and a group of  24 apparently healthy subjects (12 Males and 12 Females) were included as a control group .  The Study was carried out from August 2013 to February 2014.The patients' age was  ranging  from 35 to 64 years old.      The results indicated a significant increase (p<0.05) in serum  FBG and TSP-1 levels in diabetic patients in comparing with healthy groups.     The results  also revealed no significant differences (p> 0.05)  in serum TSP-1 levels  between  males and females in both patients and  healthy groups, while the results of FBG levels  significantly (p<0.05) increase in females than males in both patients and healthy groups.    The results have been shown significant positive correlation (P<0.05) between TSP-1 and FBG in (males and females), males, females DM patients.    The present study concluded that  Thrombospondin-1 were marker for detection and diagnosis of diabetic patients type 2.