Author:
Kadhum Hussein Majid,Ali Hamza Asia,Abdulzahra Ahmed Ali
Abstract
Adiponectin is a cytokine released from adipose tissue and may have an influence on many metabolic pathways, including insulin resistance and T2DM.
Aim: To find the relationship between adiponectin and IR and its effect on glucose level in T2DM patients in Iraqi population.
Method: This study has a two hundred participants (control) and another two hundred T2DM patients. The affirming of T2DM was introduced following criteria of WHO. FBG and HOMA-IR were also measured.
Results: A significant correlation between IR and T2DM with a significant reciprocal relationship between adiponectin level HOMA-IR.
Conclusion: The present study clarifies that T2DM patients have a significant low level of adiponectin. Adiponectin has a glucose and IR lowering effect as low level of adiponectin is associated with increased IR and hyperglycemia
Reference12 articles.
1. Megan L. Gow, Sarah P. Garnett Louise A. Baur and Natalie B., Lister (2016),The Effectiveness of Different Diet Strategies to Reduce Type 2 Diabetes Risk in Youth nutrients. 1-13 9 August.
2. Brunetti A, Chiefari E, Foti D (2014). Recent advances in the molecular genetics of type 2 diabetes mellitus. World J Diabetes; 5(2): 128-140.
3. Donath MY, StorlingJ, BerchtoldLA, BillestrupN, Mandrup PoulsenT(2008),Cytokines and beta - cell biology: from concept to clinical translation. Endocrine Reviews; 29: 334 – 350.
4. Boden G. 1 and G. I. Shulman, (2002), Free fatty acids in obesity andtype 2 diabetes: defining their role in the development of insulin resistance and β-cell dysfunction,European Journal of Clinical Investigation Volume 32, Issue Supplement s3,. pages 14–23, June.
5. Wang H, Junlong Wu, Weijie Gu, Beihe Wang. Fangning Wan,1,2 Bo Dai, et al (2016) ,Serum Adiponectin Level May be an Independent Predictor of Clear Cell Renal Cell Carcinoma,; 7(10): 1340-1346. doi: 10.7150/jca.14716.