Author:
Perry George, ,Lee Hyoung-gon,Lee Hyun Pil,Zhu Xiongwei,Smith Mark A.,Rolston Raj K.,Marlatt Michael W.,Castellani Rudy J.,Nunomura Akihiko,Casadesus Gemma,Clark Timothy A., , , , , , ,
Abstract
Oxidative imbalance is one of the earliest manifestations of Alzheimer disease (AD) actually preceding the classic pathology of amyloid β deposits and neurofibrillary tangles. Clinical trials examining antioxidant modulation by a number of global interventions show efficacy, while simple supplementation has limited benefit suggesting complexity of multiple contributing factors. In this review, we highlight new insights regarding novel approaches to understanding and treating AD based on holistic views of oxidative balance including diet.
Publisher
International Assotiation of Biomedical Sciences
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
1 articles.
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