Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism

Author:

Doeppner Thorsten R.123,Coman Cristin4,Burdusel Daiana5,Ancuta Diana-Larisa46,Brockmeier Ulf7,Pirici Daniel Nicolae5,Yaoyun Kuang1,Hermann Dirk M.7,Popa-Wagner Aurel78

Affiliation:

1. Department of Neurology, University Medical Center Göttingen, Göttingen 37075, Germany

2. Research Institute for Health Sciences and Technologies (SABITA), Medipol University, Istanbul, Turkey

3. Department of Anatomy and Cell Biology, Medical University of Varna, Varna, Bulgaria

4. Cantacuzino National Medico-Military Institute for Research and Development, Bucharest 050096, Romania

5. Department of Biochemistry, University of Medicine and Pharmacy Craiova, Craiova 200349, Romania

6. Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, Bucharest, Romania

7. Vascular Neurology and Dementia, Department of Neurology, University of Medicine Essen, Essen 45147, Germany

8. Experimental Research Center for Normal and Pathological Aging, ARES, University of Medicine and Pharmacy Craiova, Craiova 200349, Romania

Publisher

Impact Journals, LLC

Subject

Cell Biology,Aging

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