Tyrosine kinase receptor RON activates MAPK/RSK/CREB signal pathway to enhance CXCR4 expression and promote cell migration and invasion in bladder cancer

Author:

Chen Junfeng12,Wang Kejie12,Ye Shazhou12,Meng Xiangyu12,Jia Xiaolong2,Huang Youju3,Ma Qi124

Affiliation:

1. Translational Research Laboratory for Urology, The Key Laboratory of Ningbo City, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang, China

2. Ningbo Clinical Research Center for Urological Disease, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang, China

3. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, Zhejiang, China

4. Comprehensive Urogenital Cancer Center, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang, China

Publisher

Impact Journals, LLC

Subject

Cell Biology,Aging

Reference45 articles.

1. Cancer statistics, 2018.;Jemal;CA Cancer J Clin,2018

2. Bladder cancer in 2010: how far have we come?;Montie;CA Cancer J Clin,2010

3. Maximizing cure for muscle-invasive bladder cancer: integration of surgery and chemotherapy.;Herr;Eur Urol,2011

4. VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs.;Fang;Am J Cancer Res,2018

5. Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer.;Wei;Cell Rep,2019

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