Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality

Author:

Huang Shihao1,Li Yingchun12,Wang Bingjie1,Zhou Zhihao1,Li Yonglong13,Shen Lingjun4,Cong Jinge13,Han Liuxin5,Xiang Xudong6,Xia Jiawei5,He Danhua1,Zhao Zhanlin7,Zhou Ying1,Li Qiwen1,Dai Guanqi1,Shen Hanzhang5,Lin Taoyan8,Wu Aibing9,Jia Junshuang1,Xiao Dong13,Li Jing10,Zhao Wentao7,Lin Xiaolin2

Affiliation:

1. Cancer Research Institute, Experimental Education and Administration Center, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China

2. Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou 510315, China

3. Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China

4. Department of Tuberculosis, Yunnan Clinical Medical Center for Infectious Diseases, The Third People's Hospital of Kunming (The Sixth Affiliated Hospital of Dali University), Kunming 650041, China

5. Yunnan Clinical Medical Center for Infectious Diseases, The Third People’s Hospital of Kunming (The Sixth Affiliated Hospital of Dali University), Kunming 650041, China

6. Department of Thoracic Surgery, Peking University Cancer Hospital Yunnan (Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University), Kunming 650118, China

7. Department of Gastrointestinal Oncology, Peking University Cancer Hospital Yunnan (Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University), Kunming 650118, China

8. Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

9. Central People’s Hospital of Zhanjiang, Zhanjiang 524000, China

10. Radiotherapy Center, the First People’s Hospital of Chenzhou, Xiangnan University, Chenzhou 423000, China

Publisher

Impact Journals, LLC

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