TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: A potential novel approach to the treatment of metastatic colorectal cancer

Author:

Tarpgaard Line S.1,Ørum-Madsen Maj Sofie2,Christensen Ib J.3,Nordgaard Cathrine2,Noer Julie2,Guren Tormod K.4,Glimelius Bengt5,Sorbye Halfdan67,Ikdahl Tone8,Kure Elin H.9,Tveit Kjell M.8,Nielsen Hans J.10,Pfeiffer Per1,Brünner Nils2,Moreira José M. A.2

Affiliation:

1. Department of Oncology, Odense University Hospital, Odense, Denmark and University of Southern Denmark, Odense, Denmark

2. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

3. The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark and Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark

4. Department of Oncology and K. G. Jebsen Centre for Colorectal Cancer Research, Oslo University Hospital Oslo, Norway

5. Departments of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala and Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden

6. Department of Oncology, Haukeland University Hospital, Bergen, Norway

7. Department of Clinical Science, University of Bergen, Bergen, Norway

8. Department of Oncology, Oslo University Hospital, Oslo, Norway

9. Department of Genetics, Oslo University Hospital, Oslo, Norway

10. Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark

Publisher

Impact Journals, LLC

Subject

Oncology

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