PP2A inhibitors arrest G2/M transition through JNK/Sp1-dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21

Author:

Gong Fei-Ran12345,Wu Meng-Yao1,Shen Meng1,Zhi Qiaoming6,Xu Ze-Kuan7,Wang Rong1,Wang Wen-Jie1,Zong Yang78,Li Zeng-Liang7,Wu Yadi910,Zhou Binhua P.1110,Chen Kai1,Tao Min1121314,Li Wei114

Affiliation:

1. Departments of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, China

2. Departments of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China

3. Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China

4. Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China

5. Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China

6. Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China

7. Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China

8. Department of General Surgery, the Changshu No.1 People's Hospital, Changshu, China

9. Departments of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY, USA

10. Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, USA

11. Departments of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA

12. Jiangsu Institute of Clinical Immunology, Suzhou, China

13. Institute of Medical Biotechnology, Soochow University, Suzhou, China

14. PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, China

Publisher

Impact Journals, LLC

Subject

Oncology

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