Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients

Author:

Trino Stefania1,Iacobucci Ilaria2,Erriquez Daniela3,Laurenzana Ilaria1,De Luca Luciana1,Ferrari Anna2,Luserna Di Rorà Andrea Ghelli2,Papayannidis Cristina2,Derenzini Enrico2,Simonetti Giorgia2,Lonetti Annalisa4,Venturi Claudia2,Cattina Federica5,Ottaviani Emanuela2,Abbenante Maria Chiara2,Russo Domenico5,Perini Giovanni3,Musto Pellegrino6,Martinelli Giovanni2

Affiliation:

1. Laboratory of Pre-Clinical and Translational Research, IRCCS Referral Cancer Center of Basilicata, Rionero in Vulture (PZ), Italy

2. Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. and A. Seràgnoli”, University of Bologna, Bologna, Italy

3. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

4. Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy

5. Chair of Hematology and BMT Unit, University of Brescia, Brescia, Italy

6. Scientific Direction, IRCCS Referral Cancer Center of Basilicata, Rionero in Vulture (PZ), Italy

Publisher

Impact Journals, LLC

Subject

Oncology

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