Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

Author:

Barbier-Torres Lucía1,Delgado Teresa C.1,García-Rodríguez Juan L.1,Zubiete-Franco Imanol1,Fernández-Ramos David1,Buqué Xabier2,Cano Ainara3,Juan Virginia Gutiérrez-de1,Fernández-Domínguez Itziar1,Lopitz-Otsoa Fernando1,Fernández-Tussy Pablo1,Boix Loreto45,Bruix Jordi45,Villa Erica6,Castro Azucena3,Lu Shelly C.7,Aspichueta Patricia2,Xirodimas Dimitris8,Varela-Rey Marta1,Mato José M.1,Beraza Naiara1,Martínez-Chantar María L.1

Affiliation:

1. CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Bizkaia Science and Technology Park, Derio, Bizkaia, Spain

2. Department of Physiology, University of the Basque Country UPV/EHU, Faculty of Medicine and Dentistry, Leioa, Bizkaia, Spain

3. OWL, Bizkaia Science and Technology Park, Derio, Bizkaia, Spain

4. Barcelona-Clínic Liver Cancer Group, Institut d’Investigacions Biomèdiques August Pi I Sunyer, Liver Unit, Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain

5. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain

6. Department of Gastroenterology, Azienda Ospedaliero-Universitaria & University of Modena and Reggio Emilia, Modena, Italy

7. Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USC Research Center for Liver Diseases, Keck School of Medicine, Los Angeles, CA, USA

8. Centre de Recherche de Biochimie Macromoléculaire, Montpellier, France

Publisher

Impact Journals, LLC

Subject

Oncology

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