Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma

Author:

Lee Sang-Hyun1,Jeung In Cheul2,Park Tae Woo3,Lee Kyungmin13,Lee Dong Gwang13,Cho Young-Lai4,Lee Tae Sup5,Na Hee-Jun6,Park Young-Jun1,Lee Hee Gu1,Jeong Mun Sik7,Bae Kwang-Hee1,Lee Sang Chul1,Lee Hyo Jin8,Kwon Young-Guen9,Hong Hyo Jeong7,Kim Jang-Seong1,Min Jeong-Ki13

Affiliation:

1. Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

2. Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

3. Department of Biomolecular Science, University of Science & Technology, Daejeon, Republic of Korea

4. Department of Chemistry, Dongguk University, Seoul, Republic of Korea

5. Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea

6. Scripps Korea Antibody Institute, Chuncheon, Republic of Korea

7. Department of Systems Immunology, College of Biomedical Science and Institute of Antibody Research, Kangwon National University, Chuncheon, Republic of Korea

8. Department of Internal Medicine and Cancer Research Institute, Chungnam National University School of Medicine, Daejeon, Republic of Korea

9. Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea

Publisher

Impact Journals, LLC

Subject

Oncology

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