Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Author:

Quin Jaclyn123,Chan Keefe T.1,Devlin Jennifer R.14,Cameron Donald P.15,Diesch Jeannine16,Cullinane Carleen1,Ahern Jessica1,Khot Amit1,Hein Nadine7,George Amee J.789,Hannan Katherine M27,Poortinga Gretchen110,Sheppard Karen E.125,Khanna Kum Kum11,Johnstone Ricky W.158,Drygin Denis12,McArthur Grant A.15810,Pearson Richard B.12513,Sanij Elaine18,Hannan Ross D.12579

Affiliation:

1. Research Division, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria, Australia

2. Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia

3. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

4. Institute for Molecular Medicine Finland, Biomedicum 2, Helsinki, Finland

5. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia

6. Josep Carreras Institute for Leukaemia Research (IJC), Campus ICO-HGTP, Badalona, Barcelona, Spain

7. The John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia

8. Department of Pathology, University of Melbourne, Parkville, Victoria, Australia

9. School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia

10. Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia

11. QIMR Berghofer Medical Research Institute, Brisbane City, Qld, Australia

12. Pimera Inc, San Diego, CA, USA

13. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

Publisher

Impact Journals, LLC

Subject

Oncology

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