Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases

Author:

Zhao Chong12,Chen Xin1,Yang Changshan1,Zang Dan1,Lan Xiaoying1,Liao Siyan1,Zhang Peiquan1,Wu Jinjie1,Li Xiaofen1,Liu Ningning13,Liao Yuning1,Huang Hongbiao1,Shi Xianping1,Jiang Lili1,Liu Xiuhua4,Dou Q. Ping5,Wang Xuejun16,Liu Jinbao1

Affiliation:

1. State Key Laboratory of Respiratory Disease, Protein Modification and Degradation Laboratory, Department of Pathophysiology, Guangzhou Medical University, Guangdong 510182, China

2. Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China

3. Guangzhou Research Institute of Cardiovascular Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510260, China

4. Institute of Environmental and Analytical Sciences, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, China

5. The Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, and Departments of Oncology, Pharmacology and Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201-2013, USA

6. Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, South Dakota 57069, USA

Publisher

Impact Journals, LLC

Subject

Oncology

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