Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways

Author:

Cheng Hsin-Lin12,Lin Chiao-Wen34,Yang Jia-Sin12,Hsieh Ming-Ju15,Yang Shun-Fa12,Lu Ko-Hsiu67

Affiliation:

1. Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

3. Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan

4. Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

5. Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan

6. Department of Orthopedics, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

7. School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

Publisher

Impact Journals, LLC

Subject

Oncology

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