Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

Author:

Wagner Renate12,Stübiger Gerald234,Veigel Daniel12,Wuczkowski Michael34,Lanzerstorfer Peter5,Weghuber Julian5,Karteris Emmanouil6,Nowikovsky Karin12,Wilfinger-Lutz Nastasia12,Singer Christian F.7,Colomer Ramón8,Benhamú Bellinda9,López-Rodríguez María Luz9,Valent Peter21011,Grunt Thomas W.1211

Affiliation:

1. Division of Oncology, Department of Medicine I, Medical University Vienna, Vienna, Austria

2. Comprehensive Cancer Center, Medical University Vienna, Vienna, Austria

3. Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria

4. Center for Biomarker Research in Medicine, Graz, Austria

5. University of Applied Sciences Upper Austria, School of Engineering and Environmental Sciences, Wels, Austria

6. Department of Biosciences, School of Health Sciences and Social Care, Brunel University London, Uxbridge, UK

7. Department of Obstetrics/Gynecology, Medical University Vienna, Vienna, Austria

8. Department of Medical Oncology, Hospital Universitario La Princesa and Spanish National Cancer Research Center (CNIO), Clinical Research Program, Madrid, Spain

9. Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Madrid, Spain

10. Division of Hematology and Hemostaseology, Department of Medicine I, Medical University Vienna, Vienna, Austria

11. Ludwig Boltzmann Cluster Oncology, Medical University Vienna, Vienna, Austria

Publisher

Impact Journals, LLC

Subject

Oncology

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