MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells

Author:

Zeng Zhihong1,Wang Rui-Yu1,Qiu Yi Hua1,Mak Duncan H.1,Coombes Kevin2,Yoo Suk Young3,Zhang Qi1,Jessen Katti4,Liu Yi5,Rommel Christian6,Fruman David A.7,Kantarjian Hagop M.1,Kornblau Steven M.1,Andreeff Michael1,Konopleva Marina1

Affiliation:

1. Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

2. Department of Biomedical Informatics, Ohio State University College of Medicine, Columbus, OH, USA

3. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

4. Oncology-Rinat Research & Development, San Diego, CA, USA

5. Wellspring Bioscience, San Diego, CA, USA

6. Roche Innovation Center Basel, Basel, Switzerland

7. Institute for Immunology, and Department of Molecular Biology and Biochemistry, University of California-Irvine, Irvine, CA, USA

Publisher

Impact Journals, LLC

Subject

Oncology

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