The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients

Author:

Fagerholm Rainer1,Schmidt Marjanka K.2,Khan Sofia1,Rafiq Sajjad3,Tapper William3,Aittomäki Kristiina4,Greco Dario1,Heikkinen Tuomas1,Muranen Taru A.1,Fasching Peter A.56,Janni Wolfgang7,Weinshilboum Richard8,Loehberg Christian R.9,Hopper John L.10,Southey Melissa C.11,Keeman Renske2,Lindblom Annika12,Margolin Sara13,Mannermaa Arto141516,Kataja Vesa17,Chenevix-Trench Georgia18,Investigators kConFab19,Lambrechts Diether2021,Wildiers Hans22,Chang-Claude Jenny23,Seibold Petra23,Couch Fergus J.24,Olson Janet E.25,Andrulis Irene L.2627,Knight Julia A.2829,García-Closas Montserrat3031,Figueroa Jonine32,Hooning Maartje J.33,Jager Agnes33,Shah Mitul34,Perkins Barbara J.34,Luben Robert35,Hamann Ute36,Kabisch Maria36,Czene Kamila37,Hall Per37,Easton Douglas F.3839,Pharoah Paul D.P.3438,Liu Jianjun40,Eccles Diana3,Blomqvist Carl41,Nevanlinna Heli1

Affiliation:

1. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

2. Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands

3. Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK

4. Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

5. Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

6. Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA

7. Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany

8. Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Mayo Medical School-Mayo Foundation, Rochester, MN, USA

9. University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

10. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia

11. Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia

12. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

13. Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden

14. School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland

15. Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland

16. Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland

17. Cancer Center, Kuopio University Hospital, Kuopio, Finland

18. Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia

19. Peter MacCallum Cancer Center, Melbourne, Victoria, Australia

20. Vesalius Research Center (VRC), VIB, Leuven, Belgium

21. Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium

22. Multidisciplinary Breast Center, Medical Oncology, University Hospital Leuven, Leuven, Belgium

23. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

24. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

25. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA

26. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada

27. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

28. Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada

29. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

30. Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK

31. Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK

32. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA

33. Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands

34. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK

35. Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

36. Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

37. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

38. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

39. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK

40. Human Genetics Division, Genome Institute of Singapore, Singapore

41. Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, HUS, Finland

Publisher

Impact Journals, LLC

Subject

Oncology

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