Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure-Reference-Cited by-同舟云学术

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure

Published:2024-05-03 Issue:1 Volume:15 Page:275-284
ISSN:1949-2553
Container-title:Oncotarget
language:en
Short-container-title:Oncotarget

Author:

Zhang Shengliang¹²³⁴,El-Deiry Wafik S.¹²³⁴⁵

Affiliation:

1. Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA

2. Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA

3. Joint Program in Cancer Biology, Lifespan Health System and Brown University, Providence, RI 02912, USA

4. Legorreta Cancer Center at Brown University, Providence, RI 02912, USA

5. Hematology/Oncology Division, Department of Medicine, Lifespan Health System and Brown University, Providence, RI 02912, USA

Publisher

Impact Journals, LLC

Reference17 articles.

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3. The SARS-CoV-2 spike protein induces lung cancer migration and invasion in a TLR2-dependent manner;Lee;Cancer Commun (Lond),2024

4. SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells;Ohneda;Front Oncol,2022

5. Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion;Shi;Cell Res,2020