BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells

Author:

Cuyàs Elisabet12,Corominas-Faja Bruna12,Muñoz-San Martín María3,Martin-Castillo Begoña24,Lupu Ruth56,Brunet Joan78,Bosch-Barrera Joaquim78,Menendez Javier A.12

Affiliation:

1. Program Against Cancer Therapeutic Resistance (ProCURE), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, Catalonia, Spain

2. Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia, Spain

3. Neuroimmunology and Multiple Sclerosis Unit, Dr. Josep Trueta University Hospital, Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia, Spain

4. Unit of Clinical Research, Catalan Institute of Oncology, Girona, Catalonia, Spain

5. Mayo Clinic, Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Rochester, MN, USA

6. Mayo Clinic Cancer Center, Rochester, MN, USA

7. Deparment of Medical Oncology, Catalan Institute of Oncology, Girona, Catalonia, Spain

8. Department of Medical Sciences, Medical School, University of Girona, Girona, Catalonia, Spain

Publisher

Impact Journals, LLC

Subject

Oncology

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