A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: a retrospective cohort study

Author:

Castelo-Branco Pedro123,Leão Ricardo145,Lipman Tatiana1,Campbell Brittany1,Lee Donghyun1,Price Aryeh1,Zhang Cindy1,Heidari Abolfazl1,Stephens Derek1,Boerno Stefan6,Coelho Hugo5,Gomes Ana5,Domingos Celia23,Apolonio Joana D.23,Schäfer Georg7,Bristow Robert G.8,Schweiger Michal R.910,Hamilton Robert4,Zlotta Alexandre411,Figueiredo Arnaldo5,Klocker Helmut7,Sültmann Holger12,Tabori Uri1

Affiliation:

1. Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

2. Regenerative Medicine Program, Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal

3. Centre for Biomedical Research (CBMR), University of Algarve, Faro, Portugal

4. Division of Urology, Department of Surgical Oncology Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada

5. Serviço de Urologia e Transplantação Renal, Centro Hospitalar Universitário Coimbra EPE, Faculty of Medicine, University of Coimbra, Coimbra, Portugal

6. Sequencing Core Facility, Max Planck Institute for Molecular Genetics, Berlin, Germany

7. Department of Urology, Medical University of Innsbruck, Innsbruck, Austria

8. Department of Radiation Oncology, Princess Margaret Cancer Center, Toronto, Ontario, Canada

9. Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

10. Cologne Center for Genomics, Cologne University, Cologne, Germany

11. Division of Urology, Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada

12. Cancer Genome Research, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany

Publisher

Impact Journals, LLC

Subject

Oncology

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