IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms

Author:

de Melo Campos Paula1,Machado-Neto João A.1,Eide Christopher A.23,Savage Samantha L.2,Scopim-Ribeiro Renata14,da Silva Souza Duarte Adriana1,Favaro Patricia15,Lorand-Metze Irene1,Costa Fernando F.1,Tognon Cristina E.23,Druker Brian J.23,Saad Sara T. Olalla1,Traina Fabiola14

Affiliation:

1. Hematology and Hemotherapy Center - University of Campinas/Hemocentro - Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, Brazil

2. Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA

3. Howard Hughes Medical Institute, Portland, Oregon, USA

4. Current address: Department of Internal Medicine, University of São Paulo at Ribeirão Preto Medical School, Ribeirão Preto, São Paulo, Brazil

5. Current address: Department of Biological Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil

Publisher

Impact Journals, LLC

Subject

Oncology

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