HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status

Author:

Weitsman Gregory1,Barber Paul R.23,Nguyen Lan K.45,Lawler Katherine3,Patel Gargi16,Woodman Natalie78,Kelleher Muireann T.9,Pinder Sarah E.78,Rowley Mark3,Ellis Paul A.7,Purushotham Anand D.7,Coolen Anthonius C.3,Kholodenko Boris N.4,Vojnovic Borivoj12,Gillett Cheryl7,Ng Tony1810

Affiliation:

1. Richard Dimbleby Department of Cancer Research, Randall Division and Division of Cancer Studies, King's College London, Guy's Medical School Campus, London, UK

2. Department of Oncology, Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK

3. Institute for Mathematical and Molecular Biomedicine, King's College London, Guy's Medical School Campus, London, UK

4. Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

5. Department of Biochemistry and Molecular Biology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, Australia

6. Sussex Cancer Centre, Brighton and Sussex University Hospitals, Royal Sussex County Hospital, Brighton, UK

7. Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, Great Maze Pond, London, UK

8. Breakthrough Breast Cancer Research Unit, Department of Research Oncology, Guy's Hospital King's College London School of Medicine, London, UK

9. Department of Medical Oncology, St George's Hospital NHS Foundation Trust, London, UK

10. UCL Cancer Institute, Paul O'Gorman Building, University College London, London, UK

Publisher

Impact Journals, LLC

Subject

Oncology

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