Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways

Author:

Jain Payal123,Silva Amanda1,Han Harry J.2,Lang Shih-Shan12,Zhu Yuankun13,Boucher Katie123,Smith Tiffany E.123,Vakil Aesha4,Diviney Patrick5,Choudhari Namrata123,Raman Pichai367,Busch Christine M.8,Delaney Tim123,Yang Xiaodong9,Olow Aleksandra K.10,Mueller Sabine91112,Haas-Kogan Daphne13,Fox Elizabeth8,Storm Phillip B.123,Resnick Adam C.1236,Waanders Angela J.3814

Affiliation:

1. Division of Neurosurgery, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

2. Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

3. Center for Data Driven Discovery in Biomedicine (D3b), The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

4. The Fred Hutchinson Cancer Research Center, Seattle, WA, USA

5. Division of Neurology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

6. Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

7. Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

8. Division of Oncology, Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

9. Division of Neurology, University of California, San Francisco, CA, USA

10. Amgen, South San Francisco, CA, USA

11. Department of Neurosurgery, University of California, San Francisco, CA, USA

12. Department of Pediatrics, University of California, San Francisco, CA, USA

13. Department of Radiation Oncology, Harvard Medical School, Boston, MA, USA

14. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

Publisher

Impact Journals, LLC

Subject

Oncology

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