O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer

Author:

Santos Sofia N.1,Junqueira Mara S.2,Francisco Guilherme2,Vilanova Manuel345,Magalhães Ana36,Baruffi Marcelo Dias7,Chammas Roger2,Harris Adrian L.8,Reis Celso A.3569,Bernardes Emerson S.1

Affiliation:

1. Department of Radiopharmacy, Nuclear Energy Research Institute, Radiopharmacy Center, São Paulo, Brazil

2. Department of Center for Translational Oncology Cellular, Biology Group, Center for Translational Oncology, Cancer Institute of the State of Sao Paulo-ICESP, Brazil

3. I3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal

4. IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal

5. ICBAS-UP - Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal

6. Department of Glycobiology in Cancer, IPATIMUP - Institute of Molecular Pathology and Immunology from the University of Porto, Porto, Portugal

7. Department of Clinical, Toxicological and Bromatological Analysis, Faculdade de Ciências Farmaceuticas de Ribeirão Preto, Universidade de São Paulo, Brazil

8. Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK

9. Department of Pathology and Oncology, Medical Faculty, University of Porto, Portugal

Publisher

Impact Journals, LLC

Subject

Oncology

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