TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome

Author:

Ribi Sebastian1,Baumhoer Daniel23,Lee Kristy4,Edison 5,Teo Audrey S.M.1,Madan Babita5,Zhang Kang6,Kohlmann Wendy K.7,Yao Fei1,Lee Wah Heng8,Hoi Qiangze8,Cai Shaojiang8,Woo Xing Yi9,Tan Patrick1510,Jundt Gernot2,Smida Jan311,Nathrath Michaela311,Sung Wing-Kin812,Schiffman Joshua D.4,Virshup David M.5,Hillmer Axel M.1

Affiliation:

1. Cancer Therapeutics & Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore

2. Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, CH-4003 Basel, Switzerland

3. Clinical Cooperation Group Osteosarcoma, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany

4. Department of Pediatrics and Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA

5. Duke-NUS Graduate Medical School Singapore, Singapore 169857, Singapore

6. Institute for Genomic Medicine, UC San Diego, La Jolla, CA 92830, USA

7. Huntsman Cancer Institute, University of Utah Health Care, Utah, UT 84112, USA

8. Computational & Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore

9. Personal Genomics Solutions, Genome Institute of Singapore, Singapore 138672, Singapore

10. Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore

11. Department of Pediatrics and Wilhelm Sander Sarcoma Treatment Unit, Technische Universität München and Pediatric Oncology Center, 81675 Munich, Germany

12. School of Computing, National University of Singapore, Singapore 117417, Singapore

Publisher

Impact Journals, LLC

Subject

Oncology

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