DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3ʹ-end GC density

Author:

Yu Bo1,Russanova Valya R.2,Gravina Silvia3,Hartley Stephen4,Mullikin James C.45,Ignezweski Alice6,Graham James6,Segars James H.7,DeCherney Alan H.7,Howard Bruce H.2

Affiliation:

1. Department of Obstetrics and Gynecology & Women's Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA

2. Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA

3. Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA

4. Comparative Genomics Unit, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

5. NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

6. Shady Grove Fertility Reproductive Science Center, Rockville, Maryland 20850, USA

7. Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA

Publisher

Impact Journals, LLC

Subject

Oncology

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