1. Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
2. Department of Internal Medicine, University of Genoa, Genoa, Italy
3. IRCCS AOU San Martino - IST, Genoa, Italy
4. Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
5. Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA