Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

Author:

Ip Laura R. H.1,Poulogiannis George2,Viciano Felipe Cia13,Sasaki Junko4,Kofuji Satoshi4,Spanswick Victoria J.5,Hochhauser Daniel5,Hartley John A.5,Sasaki Takehiko4,Gewinner Christina A.1

Affiliation:

1. Department of Cancer Biology, UCL Cancer Institute, University College London, London, UK

2. The Institute of Cancer Research, Signalling and Cancer Metabolism, London, UK

3. Faculty of Infectious and Tropical Diseases, Immunology and Infection Department, London School of Hygiene & Tropical Diseases, London, UK

4. Department of Medical Biology, Akita University School of Medicine, Akita, Japan

5. Cancer Research UK Drug-DNA Interaction Research Group, UCL Cancer Institute, University College London, London, UK

Publisher

Impact Journals, LLC

Subject

Oncology

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