Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

Author:

von Roemeling Christina A.1,Caulfield Thomas R.2,Marlow Laura3,Bok Ilah3,Wen Jiang4,Miller James L.3,Hughes Robert5,Hazlehurst Lori6,Pinkerton Anthony B.7,Radisky Derek C.3,Tun Han W.38,Kim Yon Son Betty239,Lane Amy L.5,Copland John A.3

Affiliation:

1. The Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA

2. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

3. Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA

4. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

5. Department of Chemistry, University of North Florida, Jacksonville, FL, USA

6. Modulation Therapeutics, Inc. Morgantown WV, USA

7. Conrad Prebys Center for Chemical Genomics, Sanford Burnham Medical Discovery Institute, La Jolla, CA, USA

8. Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL, USA

9. Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA

Publisher

Impact Journals, LLC

Subject

Oncology

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