Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

Author:

Andrlová Hana1,Mastroianni Justin1,Madl Josef23,Kern Johannes S.4,Melchinger Wolfgang1,Dierbach Heide1,Wernet Florian1,Follo Marie1,Technau-Hafsi Kristin4,Has Cristina4,Mittapalli Venugopal Rao4,Idzko Marco5,Herr Ricarda6,Brummer Tilman6,Ungefroren Hendrik7,Busch Hauke78910,Boerries Melanie6810,Narr Andreas1112,Ihorst Gabriele13,Vennin Claire14,Schmitt-Graeff Annette15,Minguet Susana1112,Timpson Paul14,Duyster Justus1,Meiss Frank4,Römer Winfried23,Zeiser Robert13

Affiliation:

1. Department of Hematology and Oncology, University Medical Center, Faculty of Medicine, Freiburg, Germany

2. Faculty of Biology, Albert Ludwigs University, Freiburg, Germany

3. BIOSS Centre for Biological Signalling Studies, Albert Ludwigs University Freiburg, Freiburg, Germany

4. Department of Dermatology and Venereology, University Medical Center, Freiburg, Germany

5. Department of Pneumology, University Medical Center, Freiburg, Germany

6. Institut für Molekulare Medizin und Zellforschung, University Medical Center, Freiburg, Germany

7. First Department of Medicine, University of Lübeck, Lübeck, Germany

8. German Cancer Consortium (DKTK), Freiburg, Germany

9. Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany

10. German Cancer Research Center (DKFZ), Heidelberg, Germany

11. Department of Immunology, BIOSS Center for Biological Signaling Studies, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany

12. Center of Chronic Immunodeficiency CCI, University Clinics and Medical Faculty, Freiburg, Germany

13. Clinical Trials Unit, University Medical Center, Freiburg, Germany

14. The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, Australia

15. Department of Pathology, University Medical Center, Faculty of Medicine, Freiburg, Germany

Publisher

Impact Journals, LLC

Subject

Oncology

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