Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

Author:

Hamdi Yosr1,Soucy Penny1,Adoue Véronique234,Michailidou Kyriaki56,Canisius Sander7,Lemaçon Audrey8,Droit Arnaud8,Andrulis Irene L910,Anton-Culver Hoda11,Arndt Volker12,Baynes Caroline13,Blomqvist Carl14,Bogdanova Natalia V.1516,Bojesen Stig E.171819,Bolla Manjeet K.5,Bonanni Bernardo20,Borresen-Dale Anne-Lise21,Brand Judith S.22,Brauch Hiltrud232425,Brenner Hermann122526,Broeks Annegien7,Burwinkel Barbara2728,Chang-Claude Jenny2930,Couch Fergus J.31,Cox Angela32,Cross Simon S.33,Czene Kamila22,Darabi Hatef22,Dennis Joe5,Devilee Peter3435,Dörk Thilo16,Dos-Santos-Silva Isabel36,Eriksson Mikael22,Fasching Peter A.3738,Figueroa Jonine3940,Flyger Henrik41,García-Closas Montserrat40,Giles Graham G.4243,Goldberg Mark S.4445,González-Neira Anna46,Grenaker-Alnæs Grethe21,Guénel Pascal47,Haeberle Lothar37,Haiman Christopher A.48,Hamann Ute49,Hallberg Emily50,Hooning Maartje J.51,Hopper John L.43,Jakubowska Anna52,Jones Michael53,Kabisch Maria49,Kataja Vesa5455,Lambrechts Diether5657,Marchand Loic Le58,Lindblom Annika59,Lubinski Jan52,Mannermaa Arto546061,Maranian Mel13,Margolin Sara62,Marme Frederik2763,Milne Roger L.4243,Neuhausen Susan L.64,Nevanlinna Heli65,Neven Patrick66,Olswold Curtis50,Peto Julian36,Plaseska-Karanfilska Dijana67,Pylkäs Katri6869,Radice Paolo70,Rudolph Anja29,Sawyer Elinor J.71,Schmidt Marjanka K.7,Shu Xiao-Ou72,Southey Melissa C.73,Swerdlow Anthony74,Tollenaar Rob A.E.M.75,Tomlinson Ian76,Torres Diana4977,Truong Thérèse47,Vachon Celine50,Van Den Ouweland Ans M. W.78,Wang Qin5,Winqvist Robert6869,Investigators kConFab/AOCS79,Zheng Wei72,Benitez Javier4680,Chenevix-Trench Georgia81,Dunning Alison M.13,Pharoah Paul D. P.513,Kristensen Vessela2182,Hall Per22,Easton Douglas F.513,Pastinen Tomi8384,Nord Silje21,Simard Jacques1,

Affiliation:

1. Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec, Canada

2. Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France

3. Centre National de la Recherche Scientifique, Toulouse, France

4. Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France

5. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

6. Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus

7. Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands

8. Centre de Recherche du CHU de Québec - Université Laval, Faculté de Médecine, Département de Médecine Moléculaire, Université Laval, Quebec, Canada

9. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada

10. Department of Molecular Genetics, University of Toronto, Toronto, Canada

11. Department of Epidemiology, University of California Irvine, Irvine, CA, USA

12. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany

13. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK

14. Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

15. Department of Radiation Oncology, Hannover Medical School, Hannover, Germany

16. Gynaecology Research Unit, Hannover Medical School, Hannover, Germany

17. Copenhagen General Population Study, Herlevand Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

18. Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

19. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

20. Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy

21. Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway

22. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

23. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany

24. University of Tübingen, Tübingen, Germany

25. German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany

26. Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany

27. Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

28. Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany

29. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

30. University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

31. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

32. Sheffield Cancer Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

33. Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK

34. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

35. Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

36. Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK

37. Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

38. David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA

39. Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh, UK

40. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA

41. Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

42. Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia

43. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia

44. Department of Medicine, McGill University, Montreal, Canada

45. Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Canada

46. Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain

47. Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, VilleJuif, France

48. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

49. Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany

50. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA

51. Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

52. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

53. Division of Genetics and Epidemiology, the Institute of Cancer Research, London, UK

54. Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland

55. Central Finland Hospital District, Jyväskylä Central Hospital, Jyväskylä, Finland

56. Vesalius Research Center, Leuven, Belgium

57. Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium

58. University of Hawaii Cancer Center, Honolulu, HI, USA

59. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

60. Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland

61. Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland

62. Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden

63. National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany

64. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA

65. Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

66. Multidisciplinary Breast Center, Department of Oncology, University Hospitals Leuven, Leuven, Belgium

67. Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia

68. Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland

69. Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland

70. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione Istituto Di Ricovero e Cura a Carattere, Scientifico, Istituto Nazionale Tumori, Milan, Italy

71. Research Oncology, Guy's Hospital, King's College London, London, UK

72. Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA

73. Department of Pathology, The University of Melbourne, Melbourne, Australia

74. Division of Genetics and Epidemiology & Division of Breast Cancer Research, The Institute of Cancer Research, London, UK

75. Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands

76. Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK

77. Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia

78. Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

79. Peter MacCallum Cancer Center, the University of Melbourne, Melbourne, Australia

80. Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain

81. Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia

82. Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway

83. Department of Human Genetics, McGill University, Montreal, Quebec, Canada

84. McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada

Publisher

Impact Journals, LLC

Subject

Oncology

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