The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies
Author:
Affiliation:
1. GenFleet Therapeutics (Shanghai) Inc., Shanghai 201203, P.R. China
2. Sellas Life Sciences Group, New York, NY 10036, USA
Publisher
Impact Journals, LLC
Subject
Oncology
Reference11 articles.
1. Cyclin-Dependent Kinase Inhibitors in Hematological Malignancies-Current Understanding, (Pre-)Clinical Application and Promising Approaches;Maletzki;Cancers (Basel),2021
2. Targeting CDK9 for Anti-Cancer Therapeutics;Strebhardt;Cancers (Basel),2021
3. CDK9 inhibitors in acute myeloid leukemia;Giordano;J Exp Clin Cancer Res,2018
4. Taming of the beast: shaping Myc-dependent amplification;Levens;Trends Cell Biol,2015
5. Targeting transcription cycles in cancer;Johnstone;Nat Rev Cancer,2022
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1. CDK Inhibitors and FDA: Approved and Orphan;Cancers;2024-04-19
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