Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pARser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy

Author:

Gravina Giovanni Luca1,Marampon Francesco1,Sanità Patrizia1,Festuccia Claudio2,Forcella Chiara1,Scarsella Luca2,Jitariuc Anna2,Vetuschi Antonella2,Sferra Roberta2,Colapietro Alessandro2,Carosa Eleonora1,Dolci Susanna3,Lenzi Andrea4,Jannini Emmanuele A.5

Affiliation:

1. Department of Biotechnological and Applied Clinical Sciences, Laboratory of Prostate Onco-pathology and Experimental Endocrinology, University of L'Aquila, 67100 L'Aquila, Italy

2. Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy

3. Department of Biomedicine and Prevention, Section of Anatomy, Tor Vergata University of Rome, 00133 Rome, Italy

4. Department of Experimental Medicine, Chair of Endocrinology, Sapienza University of Rome, 00161 Rome, Italy

5. Department of Systems Medicine, Chair of Endocrinology and Medical Sexology (ENDOSEX), Tor Vergata University of Rome, 00133 Rome, Italy

Publisher

Impact Journals, LLC

Subject

Oncology

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