A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

Author:

Dai Xiaoyun1,Wang Lingzhi12,Deivasigamni Amudha3,Looi Chung Yeng4,Karthikeyan Chandrabose5,Trivedi Piyush5,Chinnathambi Arunachalam6,Alharbi Sulaiman Ali6,Arfuso Frank7,Dharmarajan Arunasalam7,Goh Boon Cher128,Hui Kam Man391011,Kumar Alan Prem121213,Mustafa Mohd Rais4,Sethi Gautam1614

Affiliation:

1. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

2. Cancer Science Institute of Singapore, Centre for Translational Medicine, Singapore

3. Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore

4. Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

5. School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India

6. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

7. Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth WA, Australia

8. Department of Haematology-Oncology, National University Health System, Singapore

9. Institute of Molecular and Cell Biology, A*STAR, Biopolis Drive Proteos, Singapore

10. Cancer and Stem Cell Biology Program, Duke-National University of Singapore Graduate Medical School, Singapore

11. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

12. Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth WA, Australia

13. Department of Biological Sciences, University of North Texas, Denton, Texas, USA

14. School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth WA, Australia

Publisher

Impact Journals, LLC

Subject

Oncology

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