Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

Author:

Wang Lingzhi12,Linus Chan Chong En13,Wong Andrea Li-Ann14,Wong Fang Cheng1,Lim Siew Woon34,Chinnathambi Arunachalam5,Alharbi Sulaiman Ali5,Lee Lawrence Soon-U2,Soo Ross14,Yong Wei Peng14,Lee Soo Chin14,Ho Paul Chi-Lui3,Sethi Gautam256,Goh Boon Cher124

Affiliation:

1. Cancer Science Institute of Singapore, National University of Singapore, Singapore

2. Department of Pharmacology, National University Health System, Singapore

3. Department of Pharmacy, National University of Singapore, Singapore

4. Department of Haematology-Oncology, National University Health System, Singapore

5. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

6. School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth WA, Australia

Publisher

Impact Journals, LLC

Subject

Oncology

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