DNA methylation-based measures of biological age: meta-analysis predicting time to death

Author:

Chen Brian H.123,Marioni Riccardo E.456,Colicino Elena7,Peters Marjolein J.8,Ward-Caviness Cavin K.9,Tsai Pei-Chien10,Roetker Nicholas S.11,Just Allan C.7,Demerath Ellen W.11,Guan Weihua12,Bressler Jan13,Fornage Myriam1314,Studenski Stephanie1,Vandiver Amy R.15,Moore Ann Zenobia1,Tanaka Toshiko1,Kiel Douglas P.1617,Liang Liming1819,Vokonas Pantel18,Schwartz Joel18,Lunetta Kathryn L.220,Murabito Joanne M.221,Bandinelli Stefania22,Hernandez Dena G.23,Melzer David24,Nalls Michael23,Pilling Luke C.24,Price Timothy R.23,Singleton Andrew B.23,Gieger Christian925,Holle Rolf26,Kretschmer Anja925,Kronenberg Florian27,Kunze Sonja925,Linseisen Jakob9,Meisinger Christine9,Rathmann Wolfgang28,Waldenberger Melanie925,Visscher Peter M.4629,Shah Sonia629,Wray Naomi R.6,McRae Allan F.629,Franco Oscar H.30,Hofman Albert1830,Uitterlinden André G.830,Absher Devin31,Assimes Themistocles32,Levine Morgan E.33,Lu Ake T.33,Tsao Philip S.3234,Hou Lifang3536,Manson JoAnn E.37,Carty Cara L.38,LaCroix Andrea Z.39,Reiner Alexander P.4041,Spector Tim D.10,Feinberg Andrew P.153,Levy Daniel242,Baccarelli Andrea743,van Meurs Joyce8,Bell Jordana T.10,Peters Annette9,Deary Ian J.444,Pankow James S.11,Ferrucci Luigi1,Horvath Steve3344

Affiliation:

1. Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA

2. The NHLBI’s Framingham Heart Study, Framingham, MA 01702, USA

3. Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA

4. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK

5. Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK

6. Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia

7. Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA

8. Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, 3000 CA, The Netherlands

9. Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany

10. Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK

11. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA

12. Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, 55455, ; USA

13. Human Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX, ; USA

14. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, ; USA

15. Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, ; USA

16. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, ; USA

17. Institute for Aging Research, Hebrew Senior Life, Boston, MA 02215, USA

18. Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA

19. Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA

20. Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA

21. Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA

22. Geriatric Unit, Usl Centro Toscana Florence, Italy

23. Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA

24. Epidemiology and Public Health, Medical School, University of Exeter, RILD, Exeter EX2 5DW, ; UK

25. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany

26. Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, 85764 Neuherberg, Germany

27. Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck 6020, Austria

28. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany

29. University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia

30. Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, 3015 CN, The Netherlands

31. HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA

32. Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, ; Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA

33. VA Palo Alto Health Care System, Palo Alto CA 94304, USA

34. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern UniversityChicago, IL 60611, USA

35. Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern UniversityChicago, IL 60611, USA

36. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA

37. Center for Translational Science Children’s National Medical Center, George Washington University, Washington, DC 20010, USA

38. Department of Family Medicine and Public Health, University of California-San Diego, La Jolla, CA 92093-0725, ; USA

39. Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA

40. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, ; USA

41. Departments of Medicine, Molecular Biology/Genetics, Oncology, and Biostatistics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

42. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA

43. Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK

44. Department of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA

Publisher

Impact Journals, LLC

Subject

Cell Biology,Aging

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