1. INSERM, U848, F-94805 Villejuif, France
2. Institut Gustave Roussy, F-94805 Villejuif,France
3. Université Paris Sud-XI, F-94805 Villejuif,France
4. Equally contributed to this article
5. Institute of Molecular Biology and Biotechnology,Foundation for Research and Technology, Heraklion GR-71110, Crete, Greece
6. Institute of Molecular Biosciences, University ofGraz, A-8010 Graz, Austria