PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis

Author:

Li Yu-Hang1,Tong Kui-Leung1,Lu Jun-Lei2,Lin Jie-Bin3,Li Zhen-Yan1,Sang Yuan4,Ghodbane Abdelmoumin1,Gao Xue-Juan2,Tam Man-Seng5,Hu Chang-Deng67,Zhang Huan-Tian1,Zha Zhen-Gang1

Affiliation:

1. Institute of Orthopedic Diseases and Department of Bone and Joint Surgery, The First Affiliated Hospital, Jinan University, Guangzhou 510630, Guangdong, China

2. Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China

3. Department of Orthopedics, The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China

4. Department of Orthopaedic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong, China

5. IAN WO Medical Center, Macao Special Administrative Region, Macao 999078, China

6. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA

7. Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA

Publisher

Impact Journals, LLC

Subject

Cell Biology,Aging

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