Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients

Author:

Cuyàs Elisabet12,Fernández-Arroyo Salvador3,Buxó Maria2,Pernas Sonia4,Dorca Joan5,Álvarez Isabel67,Martínez Susana8,Pérez-Garcia Jose Manuel9,Batista-López Norberto10,Rodríguez-Sánchez César A.1112,Amillano Kepa13,Domínguez Severina14,Luque Maria15,Morilla Idoia4,Stradella Agostina4,Viñas Gemma5,Cortés Javier916,Verdura Sara12,Brunet Joan51718,López-Bonet Eugeni19,Garcia Margarita20,Saidani Samiha21,Joven Jorge3,Martin-Castillo Begoña21,Menendez Javier A.12

Affiliation:

1. Program Against Cancer Therapeutic Resistance (ProCURE), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, Spain

2. Girona Biomedical Research Institute (IDIBGI), Girona, Spain

3. Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, IISPV, Rovira i Virgili University, Reus, Spain

4. Department of Medical Oncology, Breast Unit, Catalan Institute of Oncology-Hospital Universitari de Bellvitge-Bellvitge Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain

5. Medical Oncology, Catalan Institute of Oncology, Girona, Spain

6. Medical Oncology Service, Hospital Universitario Donostia, Donostia-San Sebastián, Spain

7. Biodonostia Health Research Institute, Donostia-San Sebastián, Spain

8. Medical Oncology Department, Hospital de Mataró, Mataró, Barcelona, Spain

9. IOB Institute of Oncology, Hospital Quirónsalud, Madrid and Barcelona, Spain

10. Medical Oncology Service, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain

11. Medical Oncology Service, Hospital Universitario de Salamanca, Salamanca, Spain

12. Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain

13. Medical Oncology, Hospital Universitari Sant Joan, Reus, Spain

14. Medical Oncology Service, Hospital Universitario Araba, Vitoria-Gasteiz, Spain

15. Department of Medical Oncology, Hospital Universitario Central de Asturias, Oviedo, Spain

16. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

17. Hereditary Cancer Programme, Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet del Llobregat, Barcelona, Spain

18. Hereditary Cancer Programme, Catalan Institute of Oncology (ICO), Girona Biomedical Research Institute (IDIBGI), Girona, Spain

19. Department of Anatomical Pathology, Dr. Josep Trueta Hospital of Girona, Girona, Spain

20. Clinical Research Unit, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain

21. Unit of Clinical Research, Catalan Institute of Oncology, Girona, Spain

Publisher

Impact Journals, LLC

Subject

Cell Biology,Ageing

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